Neurologie

Chefarzt

Dr. med. Daniel Bittner

Spezialgebiete

Hinweis:
Es ist auch möglich, bei Dr. Bittner die Doktorarbeit zu schreiben.

Wissenschaftliche Arbeiten

Publikationen

• Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Mann
  Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
  Mol Syst Biol. 2020 Jun; 16(6): e9356.
  
• David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D. Metzger, Annika Spottke, Michael T. Heneka, Klaus Fliessbach, Anja Schneider, Stefan J. Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah Düzel
  Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults
  J Neurosci. 2019 Oct 30; 39(44): 8788–8797
  
• Wilma A. Bainbridge, David Berron, Hartmut Schütze, Arturo Cardenas-Blanco, Coraline Metzger, Laura Dobisch, Daniel Bittner, Wenzel Glanz, Annika Spottke, Janna Rudolph, Frederic Brosseron, Katharina Buerger, Daniel Janowitz, Klaus Fliessbach, Michael Heneka, Christoph Laske, Martina Buchmann, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Barbara Kofler, Stefan Teipel, Ingo Kilimann, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jessen, Chris I. Baker, Emrah Düzel
  Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment
  Alzheimers Dement (Amst) 2019 Dec; 11: 610–618
  
• Patricia Panther, Maria Kuehne, Jürgen Voges, Sven Nullmeier, Jörn Kaufmann, Janet Hausmann, Daniel Bittner, Imke Galazky, Hans-Jochen Heinze, Andreas Kupsch, Tino Zaehle
  Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans
  BMC Neurosci. 2019; 20: 20.
  
• Nicolai Franzmeier, …Daniel Bittner, …, Michael Ewers
  The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease
  Mol Psychiatry. 2019 Mar 21 : 10.1038/s41380-019-0404-6
  
• Peter Körtvelyessy, Harald Prüss, Lorenz Thurner, Walter Maetzler, Deborah Vittore-Welliong, Jörg Schultze-Amberger, Hans-Jochen Heinze, Dirk Reinhold, Frank Leypoldt, Stephanie Schreiber, Daniel Bittner
  Biomarkers of Neurodegeneration in Autoimmune-Mediated Encephalitis
  Front Neurol. 2018; 9: 668
  
• Marc Pawlitzki, Catherine M. Sweeney-Reed, Daniel Bittner, Anke Lux, Stefan Vielhaber, Stefanie Schreiber, Friedemann Paul, Jens Neumann
  CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation
  Front Neurol. 2018; 9: 1075.
  
• Marc Pawlitzki, Stefanie Schreiber, Daniel Bittner, Julia Kreipe, Frank Leypoldt, Klemens Rupprecht, Roxana O. Carare, Sven G. Meuth, Stefan Vielhaber, Peter Körtvélyessy
  CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration
  Front Neurol. 2018; 9: 1037.
  
• Emrah Düzel, …, Daniel Bittner, …, Frank Jessen
  CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume
  Alzheimers Dement (Amst) 2018; 10: 782–790.
  
• Marc Pawlitzki, Jan Teuber, Christin Campe, Markus Wagner, Claudia Schuart, Friedemann Paul, Daniel Bittner
  VZV-associated acute retinal necrosis in a patient with MS treated with natalizumab
  Neurol Neuroimmunol Neuroinflamm. 2018 Sep; 5(5): e475
  
• Peter Körtvelyessy, Hans J. Heinze, Johannes Prudlo, Daniel Bittner
  CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms?
  Front Neurol. 2018; 9: 504
  
• Nicolai Franzmeier…, Daniel Bittner, …, Michael Ewers
  Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease
  Brain. 2018 Apr; 141(4): 1186–1200.
  
• Peter Körtvelyessy, Tessa Huchtemann, Hans-Jochen Heinze, Daniel M. Bittner
  Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection
  Int J Mol Sci. 2017 Mar; 18(3): 490
  
• Ritter K, Lange C, Weygandt M, Mäurer A, Roberts A, Estrella M, Suppa P, Spies L, Prasad V, Steffen I, Apostolova I, Bittner D, Gövercin M, Brenner W, Mende C, Peters O, Seybold J, Fiebach JB, Steinhagen-Thiessen E, Hampel H, Haynes JD, Buchert R.
  Combination of Structural MRI and FDG-PET of the Brain Improves Diagnostic Accuracy in Newly Manifested Cognitive Impairment in Geriatric Inpatients.
  J Alzheimers Dis. 2016 Aug 26. [Epub ahead of print]
  
• Huchtemann T, Körtvélyessy P, Feistner H, Heinze HJ, Bittner D.
  Progranulin levels in status epilepticus as a marker of neuronal recovery and neuroprotection.
  Epilepsy Behav. 2015 Jul 23. pii: S1525-5050(15)00353-4. doi: 10.1016/j.yebeh.2015.06.022.
  
• Kasper E, Schuster C, Machts J, Bittner D, Vielhaber S, Benecke R, Teipel S, Prudlo J.
  Dysexecutive functioning in ALS patients and its clinical implications.
  Amyotroph Lateral Scler Frontotemporal Degener. 2015 Jun;16(3-4):160-71.
  
• Körtvélyessy P, Gukasjan A, Sweeny-Reed C, Heinze HJ, Thurner L, Bittner DM.
  Progranulin and Amyloid-β Levels: Relationship to Neuropsychology in Frontotemporal and Alzheimer's Disease.
  J Alzheimers Dis. 2015 Mar 16. [Epub ahead of print]
  
• Kleinschmidt M, Schoenfeld R, Göttlich C, Bittner D, Metzner JE, Leplow B, Demuth HU.
  Characterizing Aging, Mild Cognitive Impairment, and Dementia with Blood-Based Biomarkers and Neuropsychology.
  J Alzheimers Dis. 2015 Nov 27;50(1):111-26. doi: 10.3233/JAD-143189.
  
• Kasper E, Zydatiss K, Schuster C, Machts J, Bittner D, Kaufmann J, Benecke R, Vielhaber S, Teipel S, Prudlo J.
  No Change in Executive Performance in ALS Patients: A Longitudinal Neuropsychological Study.
  Neurodegener Dis. 2015 Nov 28. [Epub ahead of print]
  
• Körtvelyessy P, Krägeloh-Mann I, Mawrin C, Heinze HJ, Bittner D, Wieland I, Zenker M, Nestor P.
  Hereditary diffuse leukoencephalopathy with spheroids (HDLS) with a novel CSF1R mutation and spinal cord involvement.
  J Neurol Sci. 2015 Nov 15;358(1-2):515-7. doi: 10.1016/j.jns.2015.09.370. Epub 2015 Sep 28
  
• Machts J, Bittner V, Kasper E, Schuster C, Prudlo J, Abdulla S, Kollewe K, Petri S, Dengler R, Heinze HJ, Vielhaber S, Schoenfeld MA, Bittner D. Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment.
  BMC Neurosci 2014 Jun;15(1):83
  
• Bittner DM, Wieseler I, Wilhelm, H, Riepe MW, Müller NG. Repetitive pupil light reflex: potential marker in Alzheimer’s disease?
  J Alzheimers Dis 2014 42(4):1469-77
  
• Doss P, Wandinger KP, Hyman BT, Panzer JA…Bittner D, …Prüss H. High prevalence of NMDA receptor IgA/IgM antibodies in different dementia subtypes.
  Ann Clin Trans Neurol 2014 Oct;1(10):822-32
  
• Kasper E, Schuster C, Machts J, Kaufmann J, Bittner D, Vielhaber S, Benecke R, Teipel S, Prudlo J. Microstructural white matter changes underlying cognitive and behavioural impairment in ALS – An in-vivo study using DTI.
  PLoS One 2014, Dec 11;9(12):e114543. doi: 10.1371/ journal.pone.0114543
  
• Schuster C, Kasper E, Machts J, Bittner D, Kaufmann J, Benecke R, Teipel S, Vielhaber S, Prudlo J.
  Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study.
  J Neurol 2013; 260:2856-64
  
• Schuster C, Kasper E, Dyrba M, Machts J, Bittner D, Kaufmann J, Mitchell AJ, Benecke R, Teipel S, Vielhaber S, Prudlo J.
  Cortical thinning and its relation to cognition in amyotrophic lateral sclerosis.
  Neurobiol Aging 2014; 35:240-6.
  
• Bittner DM, Heinze HJ, Kaufmann J.
  Association of 1H-MR Spectroscopy and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease: diverging behaviour at three different brain regions.
  J Alzheimers Dis 2013; 36:155-63.
  
• Bueche CZ, Garz C, Kropf S, Bittner D, Li W, Goertler M, Heinze HJ, Reymann K, Braun H, Schreiber S.
  NAC changes the course of cerebral small vessel disease in SHRSP and reveals new insights for the meaning of stases – a randomized controlled study.
  Exp Transl Stroke Med 2013;5:5
  
• Bittner DM, Bittner V, Riepe MW.
  Verbal episodic memory and endogenous estradiol – an association in patients with Mild cognitive impairment and Alzheimer’s disease
  Curr Geront Geriatr Res 2011; doi: 10.1155/2011/673012
  
• Bittner V, Ullrich G, Thormann M, Müller NG, Friederichs C, Amthauer H, Heinze HJ, Bittner DM.
  Positive FP-CIT SPECT (DaTSCAN) in clinical Alzheimer’s disease – an unexpected finding?
  Dement Geriatr Cogn Disord Extra 2011; DOI:10.1159/000330470
  
• Bittner DM, Müller NG, Bittner V.
  Nutzen des DatScan bei möglicher Lewy Body Demenz
  Klinische Neurophysiologie 2010;41:162-164
  
• Müller NG, Bittner DM
  Frühdiagnose der möglichen Alzheimererkrankung anhand neuer Forschungskriterien
  Klinische Neurophysiologie 2010;41:106-115.
  
• Bittner DM.
  Combination therapy of acetylcholinesterase inhibitor and vitamin E in Alzheimer’s Disease
  J Clin Psychopharmacol 2009;29:511-513
  
• Beinhoff U, Tumani H, Brettschneider J, Bittner D, Riepe MW
  Gender-specificities in Alzheimer's disease and mild cognitive impairment.
  J Neurol. 2008;255:117-122
  
• Beinhoff U, Hilbert V, Bittner D, Grön G, Riepe MW
  Screening for cognitive impairment: a triage of outpatient care.
  Dement Geriatr Cogn Disord. 2005;20:278-285
  
• Bittner D, Gron G, Schirrmeister H, Reske SN, Riepe MW
  [18F]FDG-PET in patients with Alzheimer's disease: marker of disease spread.
  Dement Geriatr Cogn Disord. 2005;19(1):24-30.
  
• Bittner D, Grön G
  Morbus Alzheimer – Diagnostik und Therapie
  Nervenheilkunde 2005; 24: 591-600
  
• Riepe MW, Riss S, Bittner D, Huber R
  Screening for cognitive impairment in patients with acute stroke.
  Dement Geriatr Cogn Disord. 2004;17(1-2):49-53
  
• Gron G, Bittner D, Schmitz B, Wunderlich AP, Tomczak R, Riepe MW
  Variability in memory performance in aged healthy individuals: an fMRI study.
  Neurobiol Aging. 2003 May-Jun;24(3):453-62
  
• Gron G, Bittner D, Schmitz B, Wunderlich AP, Riepe MW
  Subjective memory complaints: objective neural markers in patients with Alzheimer's disease and major depressive disorder. Ann Neurol. 2002 Apr;51(4):491-8
  
• Gron G, Bittner D, Schmitz B, Wunderlich AP, Tomczak R, Riepe MW
  Hippocampal activations during repetitive learning and recall of geometric patterns.
  Learn Mem. 2001 Nov-Dec;8(6):336-45

Beruflicher Werdegang

seit 2019	Chefarzt der Klinik für Neurologie Südharzklinikum Nordhauen gGmbH
	Ärztliche Tätigkeit in Ulm, Magdeburg
	Studium der Humanmedizin in Tübingen